Conceptualization, methodology, resources, formal analysis and funding acquisition, L.L.<\/li>\n<\/ul>\n
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The minimum distance between the latent representation and any reference prototype is used as a proxy for uncertainty for unknown cell type detection. ScPoli\u2019s training objective includes a supervised term we call prototype loss. This term has the objective of pulling together cells belonging to the same cell type towards their correspondent prototype in latent space. Unlabeled prototypes offer good reference points for downstream analyses and novel cell type annotation but are not used for the prototype loss computation.<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"
We included a scPoli model with standard OHE vectors to represent batch, and a scPoli model trained without prototype loss. We found the prototype loss to be the driver of<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[564],"tags":[],"_links":{"self":[{"href":"http:\/\/ewozz.in\/index.php\/wp-json\/wp\/v2\/posts\/3653"}],"collection":[{"href":"http:\/\/ewozz.in\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/ewozz.in\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/ewozz.in\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/ewozz.in\/index.php\/wp-json\/wp\/v2\/comments?post=3653"}],"version-history":[{"count":1,"href":"http:\/\/ewozz.in\/index.php\/wp-json\/wp\/v2\/posts\/3653\/revisions"}],"predecessor-version":[{"id":3654,"href":"http:\/\/ewozz.in\/index.php\/wp-json\/wp\/v2\/posts\/3653\/revisions\/3654"}],"wp:attachment":[{"href":"http:\/\/ewozz.in\/index.php\/wp-json\/wp\/v2\/media?parent=3653"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/ewozz.in\/index.php\/wp-json\/wp\/v2\/categories?post=3653"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/ewozz.in\/index.php\/wp-json\/wp\/v2\/tags?post=3653"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}